Effect of metoprolol in acute coxsackievirus B3 murine myocarditis
نویسندگان
چکیده
منابع مشابه
Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis.
To date, there is no universally accepted therapy for viral myocarditis. We investigated the effect of the angiotensin converting enzyme inhibitor captopril on both early and late phases of coxsackievirus murine myocarditis. Mice were infected with coxsackievirus B3 and were divided into two main protocols. Mice in the early treatment protocol (n = 30) were treated on day 1 after infection with...
متن کاملMesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis
AIMS Coxsackievirus B3 (CVB3)-induced myocarditis, initially considered a sole immune-mediated disease, also results from a direct CVB3-mediated injury of the cardiomyocytes. Mesenchymal stem cells (MSCs) have, besides immunomodulatory, also anti-apoptotic features. In view of clinical translation, we first analysed whether MSCs can be infected by CVB3. Next, we explored whether and how MSCs co...
متن کاملRT-PCR Detection of Coxsackievirus B3: A Viral Myocarditis
Backgrounds and Aims: Coxsakievirus B3 (CVB3), one of the six Coxsakievirus B serotypes, is a member of the Enterovirus genus within the Picornaviridae family. CVB3 is an important pathogen of viral myocarditis, which accounts for more than 50% of viral myocarditis cases. The genome of CVB3, like that of other Entroviruses, is a single-stranded, sense, polyadenylated RNA molecule with 7400 nucl...
متن کاملHeart-specific autoantibodies following murine coxsackievirus B3 myocarditis
The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the p...
متن کاملExpression of perforin in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3.
BACKGROUND Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of viral myocarditis. METHODS AND RESULTS Using a murine model of acute myocarditis caused by coxsackievirus B3, we analyzed the phenotypes and morphology of the infiltrating cells in the hearts by immunofluorescence and electron microscopy. We also examined the expression of a cytolytic factor, perforin, i...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1988
ISSN: 0735-1097
DOI: 10.1016/0735-1097(88)90414-7